It was also strange for the last ending to be happy when the others were either bittersweet or tragic, but the game is better with Ending E than without it, despite its flaws. Unfortunately, this causes the sacrifice that players made in Ending D to feel pointless. A giant flower blooms at the Forest of Myth, with the three main protagonists finally getting to be by each other's sides again after all hope seemed lost. She is willing to do anything to bring him back and finally achieves this, rescuing Nier, who has the appearance he did in the beginning of the game. Once defeating them, Kainé reveals how she feels about the sacrifice Nier made for her and what she thinks of him. RELATED: Kingdom Hearts: 10 Things In The Trailers That Were Removed From The Games After getting inside of the tree in the Forest of Myth, she reunites with Emil and Grimoire Weiss, and the three work together so they can get Nier back as well, fighting against the administrators in the process. It also connects this installment to NieR: Automata, which is great for fans of that game while confusing for those that haven't played it. Taking place after Ending D, players now control Kainé on an adventure that leads her to saving Nier. It is unclear whether Kaine also thought of Nier romantically, though it is obvious that he was special to her.Ending E is a brand new ending that can only be found in the improved version of the game. Though the age difference between the two is still rather large, making her 20 years old at least avoids the issue of her being a teenager in this potential romance with a much older man. It's possible that she was made old enough to be considered an adult in Gestalt as in Ending C, it is revealed that Nier has romantic feelings for her. Kaine's age differs between the two different game versions, though only by a few years. However, players do get to see a softer side of Kaine the more they get to know her. She is ostracized by others because she is possessed by a shade named Tyrann. Kaine is portrayed as a cold character with a penchant for colorful language, but her hard exterior is likely a result of being an outcast. Kaine is one of the characters that Nier meets on his journey and she becomes a party companion. For those of us that are a little sad that he is being replaced in the remake, Square Enix has apparently stated that if Nier Replicant Sells 2.5 Million Copies, that it will consider adding Papa Nier to the game.īorn in the year 3341 (Gestalt) / Born in the year 3448 (Replicant) It's hard for western fans to not have a soft spot for Papa Nier, or Father Nier if you will, as he was the only version we had on the game's original release. Interestingly, Papa Nier shares his birthday of September 11th with the release date of the original Drakengard, the franchise from which the Nier series was born. Players learn in The World of Recycled Vessel DLC that Nier's wife died as a result of the Black Scrawl. Additionally, The World of Recycled Vessel DLC allowed Gestalt players to experience a younger Nier, whereas Replicant players experienced the older Nier.īe warned, there are some spoilers ahead for those who have yet to play any version of the game.ģ9 years old (Act 1) / 44 years old (Act 2) / 21 years old in The World of Recycled Vessel DLCġ85cm / 183cm in The World of Recycled Vessel DLCįor Gestalt players, or all of us stuck in the west, Papa Nier was the protagonist for us. He is very protective of his daughter Yonah and will do anything to cure her of the Black Scrawl disease that ails her. Both the Gestalt and Replicant versions of the game also present different ages for a number of characters. That means that during your playthrough, you will see the characters at two points in their life. Nier features two different acts set five years apart from one another. ![]() The game included a host of other interesting characters, some of which even featured in some form in the sequel, Nier: Automata. The west only received the Gestalt version, but the Nier Replicant remake that is set to release later this month will finally allow fans to experience the younger protagonist. RELATED: 10 Questions From Nier: Automata That Nier Replicant Can Answer The game actually had two different versions in Japan, Nier Gestalt where the protagonist was Yonah's father, and Nier Replicant, where the protagonist was Yonah's brother. Nier originally released in 2010, offering fans a brand new RPG world to explore that held many secrets and that was more than initially met the eye.
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Edinburgh (24 minutes seven minutes and 12 seconds)ĩ. Cardiff (24 minutes six minutes and 48 seconds) Bristol (26 minutes six minutes and six seconds) Gatwick (27 minutes five minutes and 54 seconds)Ħ. Luton (28 minutes nine minutes and 42 seconds)ĥ. Doncaster Sheffield (29 minutes 10 minutes and 18 seconds)Ĥ. Manchester (29 minutes nine minutes and 30 seconds) Birmingham (30 minutes 12 minutes and 24 seconds) "We expect airlines to proactively provide passengers with information about their rights when flights are disrupted." List of airports from the longest average delay per departing flight to the shortest (duration in 20 brackets):ġ. It is important consumers experience a high-quality service from both airlines and airports this year. If the cause of the disruption falls under the airline's control, passengers are eligible for compensation of up to £520, depending on the flight's duration and distance.ĬAA head of consumer Anna Bowles said: "Our data tells us that too many passengers faced disappointing levels of delays across UK airports last year. Under consumer laws, airlines are obliged to offer passengers assistance, including refreshments, communication means, and accommodation if necessary, when flights are considerably delayed. Scotland's three airports shared the seventh position (Edinburgh), joint 10th position (Aberdeen), and joint 15th position (Glasgow), whereas Cardiff joined Edinburgh in seventh place as Wales's only representative on the list. The airports in Northern Ireland made a relatively good show on the list, with Belfast International ranking 21st and Belfast City joint 22nd out of 26. Customers using Birmingham airport this summer can expect changes to walking routes as we build our £40 million new security hall, set to be ready for June 2024." Average delays rose significantly between 20 ( Photo by Getty Images) "This year, the first since 2020 not impacted by Covid, our airport is running smoothly with customers set to equal or exceed pre-pandemic numbers. After travel restrictions were lifted, the aviation industry fought hard to recover. The analysis did not include cancelled flights.Ī Birmingham Airport spokesman said: "The start of 2022 was devastated by Covid. Taking into account all scheduled and chartered departures, the average delay across all British airports was 23 minutes. On the other hand, the airport with the best performance was East Midlands, with an average delay of just 13 minutes. They were followed by Luton (28 minutes), Gatwick (27 minutes) and Bristol (26 minutes) airports. In 2022, Doncaster Sheffield - which closed in November - and Manchester airports were tied for second place in terms of poor punctuality, both experiencing an average delay of 29 minutes. Birmingham Airport has been ranked the worst in the UK, for the second year in a row (Photo by PA)įlight delays increased significantly between 20, with average waiting times for passengers being four or five times longer last year than the previous year. According to data from CAA, flyers passing through the airport in 2021 experienced an average delay of 30 minutes after their scheduled departure time. Top ten worst airlines for flight delays from UK airports - see full listīirmingham Airport has once again landed itself in the hot seat as the worst airport in the UK for flight delays, for the second year running. ![]() The results showed that some airports have a much better track record than others when it comes to keeping flights on schedule. And with so many airports to choose from in the UK, it can be hard to know which ones are more prone to delays than others.īut fear not, analysis of data from the Civil Aviation Authority has revealed the best and worst airports in the UK when it comes to flight delays. Travelling can be an exciting experience, but nothing puts a damper on a trip quite like a delayed flight.įrom missed connections to unexpected layovers, flight delays can cause major headaches for travellers. TAKE NOTE: Travelling this summer? These are the airports to avoid if you possibly can (Photo by Getty) minor news and posts about guild recruitment, Refer-A-Friend, streams, social media links etc).
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Top Software Keywords Show more Show less ![]() He heads back out to the Burkittsville woods after a new tape is discovered by some local Blair Witch “experts.” (It’s a little upsetting, as a person who remembers watching The Blair Witch Project in the theater like it was yesterday, to learn that someone who was four years old when the original came out looks like this now. James, the premise goes, is the younger brother of Heather, and he been haunted by his sister’s disappearance. We might feel a lot less safe than we used to, but the idea of being lost in the woods, which provides so many of the original’s scares, is almost a forgotten concept in an age of smartphones and Google Maps. ![]() ![]() Theoretically, a Blair Witch sequel-one in which a whole new generation of cocky kids who think their GPS and drone cameras will save them in the forest-makes a certain amount of sense. Now, when you watch the original film, we’re onto the trick-the film is less existential terror and more three idiots yelling each other’s names for 80 minutes, unable to hold a camera straight. They thought they had nothing to worry about, because none of us did. Three student filmmakers wander into a forest-what did they have to worry about? One of the deepest terrors of The Blair Watch Project was the realization that the savvy and ironic remove of Heather, Josh, and Mike was what doomed them. It felt like the world had been, sort of, solved. In the last year of the twentieth-century we weren’t at war, the internet was making the world smaller in what seemed to be a good way, and the economy was humming. But even with that, I’d argue the scariest thing about the original Blair Witch is how it meticulously stripped away the protective illusion that we were all safe. The found footage, the fake website, and the anonymity of the actors, meant that millions of audience members mistook it for a documentary. You might not believe me, but the original The Blair Witch Project, when it came out in 1999, was one of the scariest movies I had ever seen. ![]() With turbulent times ahead, it becomes crucial to know that the people around you are going to be all hands on deck. “Offering local solutions is the key to growth and success for ecommerce.” This means balancing the needs of each region individually. We've very quickly learned that we're going to have to pivot on that,” she says. “We've typically tried to set up global strategies and then roll those out and hope that they're going to be successful. For a large company like PlayStation, that has traditionally structured itself around tax, this means they are now looking at creating more legal entities, as payments become more of a driver for the corporate structure.įor them, using an app-based flow and relying on 3DS, a local change like Brexit can mean big changes behind the scenes, just to maintain the status quo.ĭowling agrees that localization is one of the major challenges facing payments. The industry is also seeing widespread changes in international regulations, making for a more complicated life, where localization is becoming increasingly important. Read more about how GE Healthcare is using payments to power its global ecommerce strategy. “Being the advocate in your business for why payments are important is only a good thing,” she adds. She credits “research, time and investment” as the best tools to ensure their work in payments will be successful. Instead of building products in the hope that customers will begin to use them, Dowling focuses on using data to show that processes are meeting existing demands: “we heavily rely on those inputs from customers,” she says. “We want to make sure we maximize opportunities that are going to keep revenue growth in our mature areas, while developing those more emerging markets,” she says. To Dowling, it’s important to look closely at prioritizing when it comes to innovation in payments-it’s all about listening to stakeholders, both on the customer and business side. Other areas of exploration for Tan will be alternative card rails, new 3DS providers, and sharing more data with issuers as further opportunities open up. “Hopefully, we get to a stage where we can do it on a transaction level rather than a BIN level,” Tan says. Where previously they had handled BIN routing manually, “month by month, quarter by quarter,” now, this is done by algorithms alone. One example of the latter, which Tan highlights, is machine learning. While innovation is an important part of the strategy, the payments team must separate developments that are rehashes of methods they’ve already used, from those that are novel innovations that may take longer to come to fruition. This year is the year of alternatives for us.” While the last few years have been focused on “riding the Covid wave,” says Tan, “this year, we do feel the pressure.” He adds, “we are tasked with saving costs and generating more revenue. ![]() The scientists believe these results could open up new avenues for testing mosaic human embryos. Ongoing research will use live-cell time-lapse imaging to better understand the relationship between aneuploidy, cell fragmentation and blastomere exclusion within the embryo. “For patients with only mosaic embryos available for transfer, these findings suggest that in some cases, these embryos will result in apparently normal pregnancies.” “While selecting embryos with a normal chromosome complement is preferred and carries a high chance of pregnancy success, it is not a guarantee,” she explained. He further explained that by the stage in which an embryo would implant into the uterus, these abnormal cells or DNA have been visibly excluded from the rest of the embryo, suggesting that imperfect IVF embryos could be considered for use in transfer and could possibly endure in utero.Īccording to Paula Amato, MD, an associate professor of obstetrics and gynecology in the OHSU School of Medicine, this discovery could positively impact IVF processes for humans in the future. As DNA-carrying cells divide and/or fragment, the embryo appears to naturally identify which blastomeres have genetic abnormalities and stop them from further development,” said Chavez. “We found that both the blastomeres and their fragments can act as trash bins within the embryo. These fragments, it seems, can serve as a sort of cellular cleanup crew. In utero and after IVF, large cells formed by the division of a fertilized egg, known as blastomeres, may break down into small pieces called cellular fragments. Using advanced time-lapse imaging and single-cell sequencing techniques to precisely track the development of mosaic embryos of a rhesus macaque, Chavez and team identified a relationship between mosaicism and two other biological processes: cell fragmentation and blastomere exclusion. ![]() Chavez, PhD, an assistant professor of reproductive and developmental sciences at ONPRC at OHSU, and an assistant professor of obstetrics and gynecology, and physiology and pharmacology in the OHSU School of Medicine, is the first to confirm mosaic embryos can adapt and persist in development in a nonhuman primate model, resulting in positive IVF outcomes. Because aneuploidy has been linked to a risk of in vitro fertilization failure, miscarriage and certain genetic orders or birth defects, mosaic embryos- those with both normal and abnormal cells-have not been considered ideal candidates for IVF transfer.įor prospective mothers who only produce mosaic embryos, this can mean the IVF journey may end before it begins. The result is a common abnormality known as aneuploidy, which occurs in as many as 80 percent of human embryos. All rights reserved.Thanks to recent research conducted by scientists at the Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University (OHSU), a new avenue to in vitro fertilization (IVF) could soon be opened for prospective parents who were previously told it was unadvisable or impossible.Ī perfect embryo contains 46 perfect chromosomes, but some have more, and others have fewer. Preimplantation genetic screening embryonic mosaicism next-generation sequencing.Ĭopyright © 2016 American Society for Reproductive Medicine. Until more data are available, patients should be encouraged to undergo another cycle to obtain euploid embryos, when possible, rather than transferring a mosaic embryo. Patients must be counseled about the risk of undetected monosomies or trisomies within a biopsy specimen as well as the risk of intrauterine fetal demise or uniparental disomy with the transfer of mosaic embryos. Transfer of embryos with mosaic trisomies 2, 7, 13, 14, 15, 16, 18, and 21 may pose the most risk of having a child affected with a trisomy syndrome however, the transfer of embryos with mosaic monosomies or other mosaic trisomies are not devoid of risk. Certain types of mosaic embryos should be preferentially transferred over others. Genetic counseling is necessary before the transfer of a mosaic embryo is considered. ![]() Euploid embryos should be preferentially transferred over mosaic embryos. This category of mosaic embryos may be characterized by decreased implantation and pregnancy potential as well as increased risk of genetic abnormalities and adverse pregnancy outcomes. Mosaic embryos may represent a third category between normal (euploidy) and abnormal (aneuploidy). The interpretation of mosaicism is complicated because the transfer of some mosaic embryos has resulted in live births. New diagnostic techniques for preimplantation genetic screening (PGS), such as next-generation sequencing, have led to increased reporting of mosaicism. ![]() Embryonic mosaicism occurs when two or more cell populations with different genotypes are present within the same embryo. ![]() Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time. ![]()
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